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As of 2023, most adults earning below 200% of the federal poverty level lacked employer-sponsored insurance, leaving out-of-pocket payment as the only option for accessing the medications unless they were a Medicaid user living in a state where the program covered the drugs

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It stimulates lipolysis (breakdown of stored fats) and inhibits lipogenesis (formation of new fat), primarily via activation of -adrenergic and AMP-activated protein kinase (AMPK) pathways

European Group for the Study of Insulin Resistance (EGIR)